# Review a dossier claim–evidence matrix

Read each claim against its linked evidence and source version. Verify that the population, comparator, endpoint, effect estimate, confidence interval or uncertainty, timepoint, and limitation match the source. Distinguish “evidence supports a factual description” from “evidence supports the proposed claim.”

Check lifecycle A/B/C posture, wording kind, permission status, MLR review, conflict handling, audience, and distribution control. Treat A as an unapproved product for which FDA approval is sought and C as an unapproved use of an already approved product for which FDA approval is sought. For both A and C, flag any safety or effectiveness characterization or conclusion, comparative claim, or promotional conclusion. Return defects by stable ID and recommend revise, hold, or scoped clearance for a named human reviewer. Never issue a blanket compliance or dissemination approval.